Two additional retrospective, uncontrolled studies were carried out in subjects who had been exposed to cyanide from fire or smoke inhalation. The most common adverse events for this study were chromaturia (n=6), pink or red skin discoloration (n=4), hypertension (n=3), erythema (n=2), and increased blood pressure (n=2). 1,6įollowing the administration of hydroxocobalamin, 50 of 69 subjects with cyanide poisoning (73%) survived. The median hydroxocobalamin dose was 5 g with a range from 4 g to 15 g. The presence of cyanide poisoning, defined by a pretreatment blood cyanide concentration ≥39 µmol/L was confirmed in 42 of the 63 patients with evaluable data (67%). Subjects had to be over 15 years of age, present with soot in the mouth and expectoration (to indicate smoke exposure), and have altered neurological status. Smoke-Inhalation StudiesA prospective, uncontrolled, open-label study spanning almost 7 years was carried out in 69 subjects who had been exposed to smoke inhalation from fires. Respiratory, thoracic, and mediastinal disorders: pleural effusion.
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